What is Reepithelialization?

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Did you know you can accelerate wound healing with proper reepithelialization? In this article we’re going to explore how. But first, what is Reepithelialization? Well. It’s super important when it comes to wound healing and the proper closure of a wound. In fact, it’s key. Reepithelialization is a natural process within the human body that allows for the regeneration and formation of new skin. Like other natural processes, it can be stalled by different factors. These factors have to be resolved in order for wound healing to progress properly. 

Factors that Cause Wound Stalling 

If the process of reepithelialization stalls or fails otherwize, the wound outcome will be negative and may even become chronic. In this case, the patient may develop a hypertrophic scar or some other malady. That’s why it’s important to  mitigate any abnormalities that may stall wound healing and reepithelialization. In addition to the reasons above, stalling may occur as a result of trauma, infection, diabetes, hypoxia, ischemia, and excessive levels of exudate. All of these factors may cause continuous inflammation due to an excessive level of inflammatory cytokines.  

Reepithelization & Chronic Wounds  

Reepithelization is the replication and migration of skin cells. When wounds aren’t chronic, cell migration happens rather quickly, within a period of one to three days. During that time period the open wound becomes closed. In the case of a chronic wound, healing can drag on and on. Keep in mind, healing can’t happen until the wound bed is fully granulated. This is why chronic wounds occur, as a result of inferior granulation. For granulation to happen properly, it relies on oxygen and other growth factors. 

What is Autologous Platelet-Rich Plasma? 

When it comes to reepithelization, a number of factors make it easier, including Autologous Platelet-Rich Plasma, which has a number of benefits when it comes to wound healing. It helps with wound regeneration and can promote vascularization in deep partial-thickness burns. PRP contains a large concentration of blood platelets, as that’s what it’s derived from through the process of centrifugation, which sorts liquids and solids. 

What is the Process of Re-epithelialization?

New epithelium produced by the body has an important role in wound healing by activating proliferation, cell migration, and the differentiation of keratinocytes. Plus, a new layer of skin will  protect all of the underlying dermal structures and help to restore the epidermal barrier, which prevents infection and stops the excessive loss of  moisture.

What do Mesenchymal Stem Cells do? 

Mesenchymal Stem Cells or MSCs are important when it comes to preventing inflammation. MSCs also play an important role in cell migration, proliferation and differentiation. 

Are there any Advanced Therapies for Reepithelialization?

Yes. In fact, there are quite a few different advanced therapies that promote reepithelialization, including collagen therapy and cellular products. 

Collagen Therapy

Wound care products that contain collagen or collagen-producing agents are effective in helping with granulation growth. They may come in the form of pads, pastes, sheets, powders, gels, and other solutions. The collagen for these products generally derives from animal tissue, including bovine skin and tendons. 

Cellular Products

Cellular and tissue-based products are also referred to as skin substitutes. These products are made with various cellular and acellular components that aim to stimulate the extracellular matrix, regrow and regenerate tissue. For the most part, cellular products contain collagen or polyglactin, while acellular products contain an actual extracellular matrix where cells can naturally migrate and therefore boost tissue regeneration.

Other Ways to Promote Reepithelialization

One important thing to consider is eating a healthy, balanced diet high in protein. Malnutrition leads to deficiencies and  imbalances in a patient’s energy and the nutrients they need to survive. Especially damaging to proper wound care is the loss of protein. Lack of protein negatively affects the immune system and wound healing, as well as the biological and molecular processes of regrowth and regeneration. Carbohydrates are also nutritionally important as they are necessary for fibroblast migration during the proliferative phase of wound healing. The inflammatory phase of healing relies on vitamins A, B, C, and D, as well as arginine, glutamine, iron, and zinc. 


Wounds become chronic when they stall in the inflammatory phase. There are a bunch of different treatments the patient could try in order to progress wound healing. For example, wound structure and function may be restored with debridement or another form of advanced wound care. It is important for the patient to eat healthy, exercise, get rid of bacterial infections and provide the wound with a moist environment. This will all promote wound re-epithelialization. 

Contact Wound Care OC for wound treatment in Orange County, CA

Dr. Faried Banimahd is a board-certified physician specializing in emergency medicine, wound care, and pain management. Our team will work with you to create an individualized treatment plan that meets your needs and unique conditions. Our clinic includes highly trained and experienced physicians, registered nurses, and certified medical staff who work together to provide you with the highest standards of wound care treatments.

To make an appointment

1533 E 4th St,

Santa Ana, CA 92701

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